Opis: Drug Discovery in Pancreatic Cancer - H Han

Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal picture of pancreatic cancer is mainly due to the lack of early diagnosis and effective treatment for patients with advanced disease. To increase the survival rate of pancreatic cancer patients, better tumor markers for diagnosis and new molecular targets for drug development are desperately needed. A lot of effort has been made in searching for pancreatic cancer-causing genes or genes associated with progression of malignant behavior in pancreatic cancer. As a result, alterations in the expression of several cancer-related genes have been identified in pancreatic tumors. The identification and characterization of these cancer-related genes have significantly increased our understanding of pancreatic cancer development, but unfortunately the treatment of pancreatic cancer has not advanced as much in the past 20 years. Over the past decade, tremendous advances have been made in the field of cancer drug discovery, particularly, in the area of molecular and genetic models and technologies. Many of those advanced models and technologies have been applied to the drug discovery processes for pancreatic cancer. In this book, a team of experts will describe the latest development in the application of these models and technologies in pancreatic cancer. The authors include basic researchers as well as clinicians who work in the front-line of the war against pancreatic cancer and have the first-hand experience on these cutting-edge tools and techniques. The book can be divided into two general areas: model systems and genomics and proteomics tools. In recent years there have been a lot of advances in the model systems for pancreatic cancer, including the further characterization of normal and cancerous pancreatic cell lines, the establishment of transgenic mouse models that recapitulate the initiation and progression of human pancreatic cancer, the development of a new xenograft model system for the evaluation of novel agents, and the establishment of a zebrafish pancreatic cancer model. The first four chapters of the book will be devoted to these models. The advances in genomics and proteomics research have made a major impact in cancer drug discovery. A number of these -omics-based tools and techniques have been applied in the pancreatic cancer drug discovery. Chapters 5-9 of the book will discuss techniques for genome-wide examination of gene expression, copy number, methylation, function and regulation. Chapters 10-11 will discuss in situ techniques for studying chromosomal and gene copy number abnormalities as well protein expression changes in cancer samples. Chapters 12-14 will focus on techniques for global examination of protein expression levels in biospecimens obtained from pancreatic cancer patients. Cancer drug discovery has become more and more target-centric.Chapter 1: Pancreatic cancer cell line models Steven Warner, Ph.D. Translational Genomics Research Institute Division of Clinical Translational Research Chapter 2: Pancreatic cancer xenograft models Manuel Hidalgo, M.D., Ph.D. Johns Hopkins University School of Medicine Chapter 3: Pancreatic cancer transgenic mouse models David A. Tuveson M.D., Ph.D. Cancer Research UK Cambridge Research Institute Chapter 4: Pancreatic cancer zebra fish models Steven Leach, M.D. Division of Surgical Oncology Johns Hopkins University School of Medicine Chapter 5: DNA microarray expression profiling Charles Gawad, M.D. School of Medicine University of California at Los Angeles Chapter 6: Array CGH profiling Robert Lucito, Ph.D. Cold Spring Harbor Laboratory Chapter 7: High throughput siRNA Spyro Mousses, Ph.D. Division of Pharmaceutical Genomics Translational Genomics Research Institute Chapter 8: miRNA profiling Glen J. Weiss, M.D University of Colorado Health Science Center Department of Hematology and Medical Oncology Chapter 9: Methylation detection and epigenetics Bernard W. Futscher, Ph.D. Arizona Cancer Center Chapter 10: Tissue microarray based IHC and FISH Anirban Maitra, MBBS The Sol Goldman Pancreatic Cancer Research Center Johns Hopkins University School of Medicine Chapter 11: Spectral Karyotyping (SKY) and M-FISH Thomas R. Dennis, Ph.D. Translational Genomics Research Institute Chapter 12: Proteomics analysis of serum and pancreatic juice Michael Goggins, M.D. The Sol Goldman Pancreatic Cancer Research Center The Johns Hopkins University School of Medicine Chapter 13: Glycomics analysis of serum and pancreatic juice samples J. Michael Pierce, Ph.D. University of Georgia Director, UGA Cancer Center Chapter 14: Protein arrays for pancreatic cancer research Raoul Tibes, M.D. Division of Pharmaceutical Genomics Translational Genomics Research Institute Chapter 15: Vaccines for pancreatic cancer Dan A. Laheru, M.D. Buntings Blaustein Cancer Research Building Room G89 Chapter 16: Molecular imaging of small animals Robert J. Gillies, Ph.D. Department of Radiology Arizona Cancer Center, MRB 138 Chapter 17 : Development of pharmacodynamic endpoint models for the evaluation of clinical activities of targeted therapeutics Amanda Baker, Ph.D. Arizona Cancer Center

Szczegóły: Drug Discovery in Pancreatic Cancer - H Han

Tytuł: Drug Discovery in Pancreatic Cancer
Autor: H Han
Producent: Springer Verlag
ISBN: 9781441911599
Rok produkcji: 2010
Ilość stron: 362
Oprawa: Twarda
Waga: 0.7 kg

Recenzje: Drug Discovery in Pancreatic Cancer - H Han