Opis: Deoxynucleoside Analogs In Cancer Therapy - G Peters

Emerging as an important new volume in the renowned Cancer Drug Discovery and Development' series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics. Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers. Throughout Deoxynucleoside Analogs in Cancer Therapy, the focus is on novel aspects of deoxynucleoside analogs in the clinical context, as well as on unexpected targets of these compounds, such as their specific activity against cell cycle-dependent kinases or oncogenes. The wealth of information presented here can be used to design rational combinations aimed at inhibiting various cellular signaling pathways, or combining inhibition of various targets. Deoxynucleoside Analogs in Cancer Therapy has been designed specifically to facilitate such an interaction between various fields. "...a top-notch overview of the current knowledge in the area of deoxynucleoside analog development and application in the treatment of cancer." -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal "...an excellent book that is suitable for researchers or clinicians with an interest in deoxynucleoside analgos and/or cancer chemotherapy." -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review JournalNucleoside Transport into Cells: The Role of Nucleoside Transporters SLC28 and SLC29 in Cancer Chemotherapy Marcal Pastor-Anglada and F. Javier Casado The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation Maria Staub and Staffan Eriksson Deoxynucleoside Kinases and Their Potential Role in Deoxynucleoside Cytotoxicity Birgitte Munch-Petersen and Jure Piskur Nucleotidases and Nucleoside Analog Cytotoxicity Sally Anne Hunsucker, Beverly S. Mitchell, and Jozef Spychala Pumping Out Drugs: The Potential Impact of ABC Transporters on Resistance to Base, Nucleoside, and Nucleotide Analogs Piet Borst and Peter Wielinga Cytosine Arabinoside: Metabolism, Mechanisms, of Resistance, and Clinical Pharmacology Isabelle Hubeek, G. J. L. Kaspers, G Ossenkoppele, and G. J. Peters Clofarabine: Mechanisms of Action, Pharmacology, and Clinical Investigation Varsha Gandhi and William Plunkett L-Nucleosides as Chemotherapeutic Agents Giuseppe Gumina, Youhoon Chong, and Chung K. Chu Troxacitabine: A Deoxycytidine Nucleoside Analogue With Potent Antitumor Activity Henriette Gourdeau and Jacques Jolivet 9-b-D-arabinofuranosylguanine Sophie Curbo Gemcitabine: Mechanism of Action and Resistance A. M. Bergman and G.J. Peters Clinical Activity of Gemcitabine as a Single Agent and in Combination J. R. Kroep, GJ Peters, and RA Nagourney Nucleoside Radiosensitizers Donna S. Shewach and Theodore S. Lawrence NONMEM Population Models of Cytosine Arabinoside and Flubaradine Phosphate in Pediatric Patients with Leukemia Vassilios I. Avramis The cycloSal-Nucleotide Delivery System: Development of Chemical Trojan Horses as Antiviral Agents Chris Meier, Jan Balzarini, and Astrid Meerbach Purine and Pyrimidine Based Analogs and Suicide Gene Therapy Zoran Gojkovic 3'-deoxy-3'- Fluorothymidine as a Tracer if Proliferation in Positron Emission Tomography

Szczegóły: Deoxynucleoside Analogs In Cancer Therapy - G Peters

Tytuł: Deoxynucleoside Analogs In Cancer Therapy
Autor: G Peters
Producent: Humana Press
ISBN: 9781588293275
Rok produkcji: 2006
Ilość stron: 490
Oprawa: Twarda
Waga: 1.9 kg

Recenzje: Deoxynucleoside Analogs In Cancer Therapy - G Peters