Opis: Biological Responses to DNA Damage

Living cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are reviewed in this volume by authors from over sixty of the world's leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is essential reading for investigators of DNA replication, cell cycle control, and tumorigenesis.Symposium Participants Foreword Mutation Response and Error Bypass (G.C. Walker, M. Radman, P.L. Foster, M.F. Goodman, E.C. Friedberg, L. Prakash, C.W. Lawrence, F. Hanaoka, T.A. Kunkel) Base Recognition and Excision Repair (E.T. Kool, G.L. Verdine, J.A. Tainer, T. Lindahl, E. Seeberg, S.H. Wilson, A. Sancar) Nucleotide Excision Repair (R.D. Wood, P.C. Hanawalt, G. Mer, P.K. Cooper) Mismatch Repair (R. Fishel, W. Yang, K. Morikawa, J.H. Miller) Telomeres and the Stability of DNA Ends (E.H. Blackburn, T. de Lange, C.W. Greider, D.E. Gottschling, L. Guarente, J.E. Haber, S.C. West) Damage Control during Replication and Mitosis (P. Nurse, J.F.X. Diffley, R. Rothstein, E.J. Foss, P. Russell, P.K. Sorger, C.L. Rieder) Genome Stability and Checkpoint Control (J.F. Ward, L.D. Samson, F.W. Alt, J.H.J. Petrini, S.J. Elledge, S.P. Jackson, R.D. Kolodner, T. Weinert, M. Yanagida, A.M. Carr, R.S. Weiss, M.O. Hengartner) p53 and the DNA Damage Response (A.J. Levine, D. Lane, C. Prives, S.W. Lowe, G. Wahl) DNA Damage and Cancer Progression (M.B. Kastan, Y. Shiloh, D.M. Livingston, J.H. Chung, M. Jasin, S.A. Leadon, A.R. Venkitaraman, I.D. Hickson, Z.-Q. Wang) Summary (E.C. Friedberg)

Szczegóły: Biological Responses to DNA Damage

Tytuł: Biological Responses to DNA Damage
Producent: Cold Spring Harbor Laboratory Press
ISBN: 9780879696061
Rok produkcji: 2001
Ilość stron: 613
Oprawa: Miękka
Waga: 1.67 kg

Recenzje: Biological Responses to DNA Damage