Opis: Targeted Delivery of Small and Macromolecular Drugs - A Narang

Site-specific drug delivery and targeting is attracting much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Bringing together leading field experts, Targeted Delivery of Small and Macromolecular Drugs summarizes current progress with a focus on the novel ideas being explored to overcome these challenges. Focuses on the Targeted Drug Delivery Technologies that Utilize both Systemic and Local Routes of Administration Leading experts discuss some of the most promising strategies for drug targeting. They also cover targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including: * Active targeting * Nucleic acid delivery and targeting * Intracellular/Organelle-Specific Strategies * Prodrug Strategies * Organ or Tissue-Specific drug delivery * Drug-Polymer Conjugates and Micelles * Stimuli-Responsive systems Targeted Delivery of Small and Macromolecular Drugs demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.Therapeutic Potential of Targeted Drug Delivery Ajit S. Narang and Ram I. Mahato ACTIVE TARGETING Antibody Therapies for Liver Malignancy and Transplantation John M. Luk and Kwong-Fai Wong Transferrin Receptor-Mediated Transcytosis in Intestinal Epithelial Cells for Gastrointestinal Absorption of Protein Drugs Nurmamet Amet, Xiaoying Chen, Hsin-Fang Lee, Jennica Zaro, and Wei-Chiang Shen Ionizing Radiation for Tumor-Targeted Drug Delivery Roberto Diaz, Li Zhou, and Dennis E. Hallahan NUCLEIC ACID DELIVERY AND TARGETING Recent Advances in Gene Expression and Delivery Systems Ravikiran Panakanti and Ram I. Mahato Cellular Barriers for Nucleic Acid Delivery and Targeting Arto Urtti Targeted Delivery Systems of Nonviral Nucleic Acid-Based Therapeutics Ga Yong Shim, Eun-Joong Kim, Rae Sung Chang, Han Young Lee, and Yu-Kyoung Oh Delivery and Targeting of Oligonucleotides and siRNA Ningning Yang and Ram I. Mahato Liposomes for Nonviral Gene Delivery Jiasheng Tu, Yan Shen, Hui Pang, and Yubing Yu INTRACELLULAR/ORGANELLE-PART SPECIFIC STRATEGIES Delivering the Bullet to the Right Intracellular Target: A Cellular Perspective on Drug Delivery Maria Teresa Tarrago-Trani and Brian Storrie Mitochondria-Targeted Drug Delivery Volkmar Weissig and Gerard G. M. D'Souza PRODRUG STRATEGIES Site-Specific Prodrug Activation Strategies for Targeted Drug Action Mark D. Erion Enzyme-Activated Prodrug Strategies for Targeted Drug Action Jarkko Rautio, Krista Laine, Lanyan Fang, Bing Han, Kristiina Huttunen, and Duxin Sun ORGAN- OR TISSUE-SPECIFIC DRUG DELIVERY Targeting Colon and Kidney: Pathophysiological Determinants of Design Strategy Ajit S. Narang and Ram I. Mahato Principles and Practice of Pulmonary Drug Delivery Vivek Gupta, Chandan Thomas, and Fakhrul Ahsan Recent Advances in Ocular Drug Delivery: Role of Transporters, Receptors, and Nanocarriers Gyan P. Mishra, Ripal Gaudana, Viral M. Tamboli, and Ashim K. Mitra POLYMER-DRUG CONJUGATES AND MICELLES Injectable Polymers for Regional Drug Delivery Rajendra P. Pawar, Niteen R. Shinde, Narsinha M. Andurkar, Satish A. Dake, and Abraham J. Domb Polymer-Drug Conjugates Lucienne Juillerat-Jeanneret and Feride Cengelli Polymer Micelles for Drug Delivery Sungwon Kim and Kinam Park STIMULI-RESPONSIVE SYSTEMS Multifunctional Stimuli-Responsive Nanoparticles for Targeted Delivery of Small and Macromolecular Therapeutics Srinivas Ganta, Arun Iyer, and Mansoor Amiji Physiological Stress Responsive Gene Regulation Systems for Tissue Targeting Hyun Ah Kim and Minhyung Lee

Szczegóły: Targeted Delivery of Small and Macromolecular Drugs - A Narang

Tytuł: Targeted Delivery of Small and Macromolecular Drugs
Autor: A Narang
Producent: CRC Press Inc.
ISBN: 9781420087727
Rok produkcji: 2009
Ilość stron: 630
Oprawa: Twarda
Waga: 1.29 kg

Recenzje: Targeted Delivery of Small and Macromolecular Drugs - A Narang