Opis: Thin Layer Chromatography in Drug Analysis

Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separation and analysis of chiral substances. The text addresses the newest advances in TLC instrumentation, two-dimensional TLC, quantification by slit scanning densitometry and image analysis, statistical processing of data, and various detection and identification methods. It also describes the use of TLC for solving a key issue in the drug market-the presence of substandard and counterfeit pharmaceutical products. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups. Each chapter contains an introduction about the structures and medicinal actions of the described substances and a literature review of their TLC analysis. A useful resource for chromatographers, pharmacists, analytical chemists, students, and R&D, clinical, and forensic laboratories, this book can be utilized as a manual, reference, and teaching source.Part I Theory of Thin Layer Chromatography in Context of Pharmaceutical Analysis Overview of Drug Analysis and Structure of the Book Lukasz Komsta, Monika Waksmundzka-Hajnos, and Joseph Sherma Chemistry of Drugs and Its Influence on Retention Oliwia Szerkus and Michal J. Markuszewski Sorbents and Layers Used in Drug Analysis Fred Rabel and Joseph Sherma Optimization of Mobile Phase Composition Miroslaw Hawryl and Anna Hawryl Chromatographic Analysis of Ionic Drugs Monika Waksmundzka-Hajnos Ionic Liquid Additives to Mobile Phases Roman Kaliszan and Michal Piotr Marszall Chromatographic Analysis of Chiral Drugs Shuchi Dixit and Ravi Bhushan Chambers, Sample Application, and New Devices in the Chromatography of Drugs Beata Polak, Radoslaw Gwarda, Ewelina Kopcial, and Tadeusz H. Dzido 2D Planar Chromatography Huba Kalasz Quantitative Detection of Drugs by Densitometry and Video Scanning Bernd Spangenberg Statistical Evaluation and Validation of Quantitative Methods of Drug Analysis Lukasz Komsta Detection and Identification in TLC Drug Analysis Lukasz Ciesla and Iwona Kowalska TLC Determination of Drug Lipophilicity Zivoslav Lj. Tesic and Dusanka M. Milojkovic-Opsenica Screening of Substandard and Fake Drugs in Underdeveloped Countries by TLC Eliangiringa Kaale, Peter Risha, Thomas Layloff, and Joseph Sherma Part II Planar Chromatography of Particular Drug Groups TLC of Antidepressants and Neuroleptics Robert Skibinski TLC of Anxiolytics and Sedatives Claudia Cimpoiu and Anamaria Hosu TLC of Morphine Analogs Grzegorz Jozwiak TLC of Nonopioid Analgesics, Anti-Inflammatics, and Antimigraine Drugs Arkadiusz Pomykalski TLC of Ergot Alkaloid Derivatives Anna Petruczynik Thin-Layer Chromatography of Anesthetics Maja M. Natic TLC of Psychostimulants Joanna Drozd TLC of Antiepileptics Beata Paw TLC of Alzheimer's Disease Medicines Lukasz Ciesla TLC of Antiparkinsonians Sigrid Mennickent, Marta de Diego, Mario Vega, and Carmen Gloria Godoy Thin-Layer Chromatography of Cardiac Drugs Rafal Pietras TLC of Antihypertensive and Antihypotensive Drugs Danica Agbaba and Katarina Nikolic TLC of Beta-Blockers and Beta-Agonists Anna Gumieniczek and Anna Berecka TLC of Antithrombotics Marica Medic-Saric, Mirza Bojic, and Zeljko Debeljak TLC of Antihyperlipidemics Lukasz Komsta TLC of Spasmolytics Przemyslaw Talik and Jan Krzek TLC of Mucolytic, Antitussive, and Antiasthmatic Drugs Radoslaw J. Ekiert and Jan Krzek TLC of Neuromuscular Blockers Dusanka M. Milojkovic-Opsenica and Maja M. Natic TLC of Antiulcers Tadeusz Inglot TLC of Antiemetic Drugs Lukasz Komsta TLC of Steroids and Analogs Rada M. Baosic TLC of Drugs Used in Obesity and Sexual Dysfunction Treatment Lukasz Komsta TLC of Prostaglandins Mariusz Stolarczyk, Anna Apola, and Jan Krzek TLC of Diuretics Urszula Hubicka, Anna Maslanka, and Jan Krzek TLC of Antidiabetics Anna Gumieniczek and Anna Berecka TLC of Antihistamines Danica Agbaba and Gordana Popovic TLC of Vitamins Including Nicotinic Acid Derivatives Alina Pyka TLC of Antiseptics Anna Apola, Mariusz Stolarczyk, and Jan Krzek TLC of Sulfonamides Irena Choma and Wioleta Jesionek TLC of Quinolones Dorota Kowalczuk Thin-Layer Chromatography of Tuberculostatic Drugs Anamaria Hosu and Claudia Cimpoiu TLC of Antifungal and Antiprotozoal Drugs Zivoslav Lj. Tesic and Jelena D. Trifkovic TLC of beta-Lactam Antibiotics Monika Dabrowska and Malgorzata Starek TLC of Other Antibiotics Malgorzata Starek and Monika Dabrowska Thin-Layer Chromatography of Antiviral Drugs Anna Gumieniczek and Anna Berecka Thin-Layer Chromatography of Anticancer Drugs Duygu Yeniceli Uncertainty Factors in the Enantioseparation of Chiral Drugs on Silica Gel Layers Mieczyslaw Sajewicz and Teresa Kowalska

Szczegóły: Thin Layer Chromatography in Drug Analysis

Tytuł: Thin Layer Chromatography in Drug Analysis
Producent: CRC Press Inc.
ISBN: 9781466507159
Rok produkcji: 2014
Ilość stron: 1067
Oprawa: Twarda
Waga: 1.97 kg

Recenzje: Thin Layer Chromatography in Drug Analysis