Opis: Extracellular Vesicles in Health and Diseases

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role in pathogenesis as well as their possible use as biomarkers. This book stems from the first international meeting on "Microvesicles and Nanovesicles in Health and Disease" held at Magdalen College, Oxford, in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose. The presentations at this meeting form the basis of this book, which will appeal to basic scientists, clinicians, and those developing technology for the measurement of extracellular vesicles.SECTION 1 OVERVIEW Overview of extracellular vesicles in health and disease - Rienk Nieuwland, Edwin van der Pol and Augueste Sturk The Biogenesis of Exosomes - Michiel Pegtel Extracellular vesicle-mediated epigenetic reprogramming of cells G.Camussi, F. Collino, M.C. Deregibus SECTION 2 TECHNOLOGIES FOR MEASUREMENT OF EXTRACELLULAR VESICLES An overview of novel and conventional methods to detect extracellular vesicles. E. van der Pol, T.G. van Leeuwen, R. Nieuwland Standardization and Pre-analytical Variables Romaric Lacroix, Coralie Judicone, Stephane Robert, Laurent Arnaud, Florence Sabatier and Francoise Dignat-George Procoagulant Assays Barry Woodhams Capture Based Assays for Extracellular Vesicles within the Blood Jean Amiral Flow Cytometry Romaric Lacroix, Stephane Robert, Florence Sabatier and Francoise Dignat-George Atomic force microscopy measurement of extracellular vesicles derived from plasma Yuana Yuana and Susanne Osanto Light scattering methods to characterize extracellular vesicles Don A Gabriel MD PhD, Sam Glover, Regina Bowling and Nigel Key Nanoparticle Tracking Analysis Rebecca Dragovic and Chris Gardiner Microvesicle and exosome proteomic analysis Extracellular vesicle proteomic analysis Andres F. Parguina and Angel Garcia SECTION 3 CLINICAL PERSPECTIVES Microvesicles and exosomes in Cancer Rebecca Karp and Jeffrey Zwicker Extracellular Vesicles and tissue factor Pierre-Emmanuel Rautou and Nigel Mackman Extracellular vesicles in normal pregnancy and pre-eclampsia Ian Sargent, Rebecca Dragovic, Dionne Tannetta and Christopher Redman Extracellular vesicles in Cardiovascular Disease Anne-Clemence Vion, and Chantal M. Boulanger Extracellular vesicles in Immunology Els J. van der Vlist, Esther N.M Nolte't Hoen and Marca H.M. Wauben

Szczegóły: Extracellular Vesicles in Health and Diseases

Tytuł: Extracellular Vesicles in Health and Diseases
Producent: Pan American Health Organisation
ISBN: 9789814411981
Rok produkcji: 2014
Ilość stron: 482
Oprawa: Twarda
Waga: 0.77 kg

Recenzje: Extracellular Vesicles in Health and Diseases