Opis: Computational Methods for Reproductive and Developmental Toxicology - Donald Mattison

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.INTRODUCTION Introduction Donald R. Mattison Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals Karen A. Augustine-Rauch REACH and Environmental Chemicals Olivier Taboureau, Karine Audouze, and Soren Brunak REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS Female Reproductive Physiology Mariangela Maluf and Paulo Marcelo Perin Maternal Recognition of Pregnancy Paulo Marcelo Perin and Mariangela Maluf Early Embryo Development and Bipotential Gonad Formation Paulo Marcelo Perin and Mariangela Maluf Assessing the Reproductive Health of Men with Occupational Exposures Steven M. Schrader, Susan Reutman, and Katherine L. Marlow REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity Aldert H. Piersma US National Library of Medicine Resources for Computational Toxicology Pertti J. Hakkinen Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations Leona A. Harris and James F. Selgrade Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk Snezana Agatonovic-Kustrin and David W. Morton Approaches for Pediatric Developmental Drug-Induced Liver Injury William F. Salminen and Xi Yang Adverse Outcome Pathways for Developmental Toxicity Damiano Portinari and Philip N. Judson

Szczegóły: Computational Methods for Reproductive and Developmental Toxicology - Donald Mattison

Tytuł: Computational Methods for Reproductive and Developmental Toxicology
Autor: Donald Mattison
Producent: Taylor
ISBN: 9781439861073
Rok produkcji: 2013
Ilość stron: 344
Oprawa: Twarda
Waga: 0.66 kg

Recenzje: Computational Methods for Reproductive and Developmental Toxicology - Donald Mattison