Opis: Arsenic - Christopher States

This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposureSection I: Fundamentals of Arsenic Exposure and Metabolism Chapter 1: History of Arsenic as a Poison and Medicinal 4 Chapter 2: Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils Distribution, Nature, Origin & Human Exposure Routes 34 Chapter 3: Remediation of Arsenic in Drinking Water 115 Chapter 4: The Chemistry and Metabolism of Arsenic 149 Section II: Epidemiology and Disease Manifestations of Arsenic Exposure Chapter 5: Human Population Studies and Nutritional Intervention 203 Chapter 6: Skin manifestations of chronic arsenicosis 230 Chapter 7: Lung cancer and other pulmonary diseases 247 Chapter 8: Bladder Cancer and Arsenic 300 Chapter 9: Neurological Effects of Arsenic Exposure 342 Chapter 10: Diabetes Mellitus 387 Chapter 11: Hepatotoxicity 428 Chapter 12: Genetic Epidemiology of Susceptibility to Arsenic-induced Diseases 457 Section III. Mechanisms of Toxicity Chapter 13: Arsenic Interaction with Zinc Finger Motifs 501 Chapter 14: Role In Chemotherapy 545 Chapter 15: Genotoxicity 607 Chapter 16: Arsenic and Signal Transduction 650 Chapter 17: Stem Cell Targeting and Alteration by Arsenic 704 Chapter 18: Epigenetics and Arsenic Toxicity 748 Section IV: Models for Arsenic Toxicology, Risk Assessment Chapter 19: Cancer Induced by Exposure to Arsenicals in Animals 779 Chapter 20: Arsenic induced cardiovascular disease 804 Chapter 21: Invertebrate Models in Arsenic Research: Past, Present & Future 835 Chapter 22: Toxicokinetics and Pharmacokinetic Modelling of Arsenic 884 Chapter 23: Considerations for a Biologically Based Risk Assessment for Arsenic 909 Chapter 24: Translating experimental data to human populations 955

Szczegóły: Arsenic - Christopher States

Tytuł: Arsenic
Autor: Christopher States
Wydawnictwo: John Wiley
ISBN: 9781118511145
Rok wydania: 2015
Ilość stron: 576
Oprawa: Twarda
Waga: 1.01 kg

Recenzje: Arsenic - Christopher States