Opis: Oral Anticoagulants - L Poller

Warfarin and related drugs have been used for over half a century in prevention and treatment of thrombotic disorders. Only recently however has their clinical role been firmly established by randomized studies and their benefit/risk ratio improved by lower dosetherapy with improvements in laboratory monitoring. An international team of recognized experts provide detailed coverage on the mode of action; clinical pharmacodynamics; magnitude and sources of variability in individuals response to oral anticoagulant; methods of individualizing dosing regimens; laboratory monitoring; and comparison between the different currently prescribed oral anticoagulants. This is a detailed and comprehensive treatise on oral anticoagulants and their clinical application...a very comprehensive book.Journal of Human HypertensionPreface; the history of the development of oral anti-coagulant drugs; structure and mechanisms of activation of vitamin K antagonists; pharmacokinetics and drug interactions with Warfarin; laboratory monitoring of anticoagulants; proteins induced by vitamin K absence (PIVKA's) - the effect of coumarins circulating clotting factors; effects of vitamin K and oral anticoagulants on human bone metabolism; human recombinant tissue factor. Development and initial studies in monitoring Warfarin; the effects of oral anti-coagulants on molecular markers of thrombosis; oral anti-coagulants in the prevention and treatment of venous throm-boembolism; atrial fibrillation and oral anticoagulants; oral anticoagulants in the secondary and primary prevention of myocardial infarction and coronary death; valvular heart disease and heart valve prosthesis; oral anticoagulants for prevention of stroke and cerebral embolism; practical dosing considerations with Warfarin and optimal therapeutic range; use of anticoagulants in pregnancy; hemorrhagic complications or oral anticoagulant therapy; oral anticoagulation therapy in paediatric patients; Warfarin in the treatment of cancer; oral anticoagulants in the elderly; indications and results with combined Warfarin and antiplatelet drugs; anti-coagulation in cardiomyopathy; rebound hypercoagulability after discontinuation of oral anticoagulants; index.

Szczegóły: Oral Anticoagulants - L Poller

Tytuł: Oral Anticoagulants
Autor: L Poller
Producent: Arnold Publishers
ISBN: 9780340552667
Rok produkcji: 1996
Ilość stron: 288
Oprawa: Twarda
Waga: 0.84 kg

Recenzje: Oral Anticoagulants - L Poller