Opis: Rho GTPases in Cancer - K van Golen

The Rho GTPases were first discovered due to their homology to Ras GTPase. Approximately 30% of human cancers harbor an activating mutation to Ras, and Ras mutations promote cell growth and survival. Due to their homology to Ras, great enthusiasm has ensued over the discovery of the Rho GTPases. It was thought that activating mutations, similar to what is seen in Ras, would be found in the Rho proteins and would account for a proportion of human cancers that did not harbor Ras mutations. After an intense survey of multiple human cancer specimens, no evidence of activating mutations were found. Instead, overexpression of Rho proteins and aberrant activation were found to be common. Aberrant activation of Rho GTPase is found to be caused by alterations in the activity of upstream Rho-regulatory proteins. Since their discovery, 22 human Rho proteins have been identified and several have been shown to be involved in cancer progression. In contrast to Ras and its closely related members, Rho proteins act as dynamic switches to alter the actin cytoskeleton. Because of this, these proteins regulate nearly all aspects of cell physiology including growth, polarity and migration. Thus, they are very important molecules in cancer biology and constitute potential and desirable therapeutic targets. The roles and importance of the Rho GTPases in cancer is just really becoming to be appreciated and the amount of new information gathered over the past 5 years has been staggering. However, there currently is no comprehensive source of information for Rho biology. Therefore, this volume could be very timely and of great interest.Table of Contents Preface i. Introduction v. Aron Jaffe and Alan Hall List of Contributors xix. Section I- An Overview of the Rho GTPases Chapter 1. Overview of Rho GTPase History 1. Ellen V. Stevens and Channing J. Der Chapter 2. Rho GTPases and Cancer 43. Devin T. Rosenthal, John Chadwick Brenner, and Sofia D. Merajver Section II- The Rho Regulatory Proteins in Cancer Chapter 3. RhoGDIs in Cancer 67. Anthony N. Anselmo, Gary M. Bokoch, and Celine DerMardirossian Chapter 4. Signaling through Galpha12/13 and RGS-RhoGEFs 93. Nicole Hajicek, Barry Kreutz and Tozu Kazasa Chapter 5. Vav Proteins In Cancer 126. Daniel D. Billadeau Chapter 6. Rho GTPase-Activating Proteins in Cancer 156. Matthew W. Grogg and Yi Zheng Section III- The Rho GTPase Proteins and Cancer Chapter 7. RhoBTB Proteins in Cancer 182. Caroline McKinnon and Harry Mellor Chapter 8. RhoC GTPase in Cancer Progression and Metastasis 197. Kenneth L. van Golen Chapter 9. RhoB GTPase and Farnesyl Transferase Inhibitors (FTIs) in Cancer 219. Minzhou Huang, Lisa D. Laury-Kleintop and George C. Prendergast Chapter 10. Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview 257. Heather Unger and Kenneth L. van Golen Chapter 11. The Rho-Regulated ROCK Kinases in Cancer 273. Grant R. Wickman, Michael Samuel, Pamela A. Lochhead and Michael F. Olson

Szczegóły: Rho GTPases in Cancer - K van Golen

Tytuł: Rho GTPases in Cancer
Autor: K van Golen
Producent: Springer Verlag
ISBN: 9781441911100
Rok produkcji: 2009
Ilość stron: 230
Oprawa: Twarda
Waga: 0.5 kg

Recenzje: Rho GTPases in Cancer - K van Golen