Opis: Life Illuminated - J Witkowski

This book is the second volume of an intellectual history of the science done at CSHL (the first volume, Illuminating Life, showed that genetics became the dominant theme of research at CSH by as early as 1904). The appointment of James Watson as Director of the Laboratory in 1968 set off the explosive research development at CSH, as he recruited widely and wisely teams of investigators with diverse scientific interests. From this collection of papers, presented in full on the accompanying CD, several themes emerge: the characterization and exploitation of mobile genetic elements; the mechanics of DNA replication and regulation of the cell cycle; the behavior and internal architecture of cells; how viruses induce tumors; the discovery of cancer genes; the characteristics of neurons; and the invention of techniques that make possible further progress. Each theme is introduced in the context of the science of the time, and each paper has a commentary by, in most cases, one of its authors. Life Illuminated is a story of scientific innovation and achievement, told in the words of the investigators themselves.Preface Jan A. Witkowski, Alexander Gann, and Joseph F. Sambrook Acknowledgments GENETICS Gerald R. Fink Introduction: Genes Are Interesting to Geneticists Rasika Harshey Ljungquist E. and Bukhari A.I. 1977. State of prophage Mu DNA upon induction. Proc. Natl. Acad. Sci. 74: 3143-3147. Bukhari Memoriam Taylor A.L. and Szybalski W. 1984. In memoriam: Ahmad I. Bukhari, 1943-1983. Gene 27: iii-iv. James B. Hicks Strathern J.N, Klar A.J.S., Hicks J.B., Abraham J.A., Ivy J.M., Nasmyth K.A., and McGill C. 1982. Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus. Cell 31: 183-192. Robert Martienssen Sundaresan V., Springer P., Volpe T., Haward S., Jones J.D.G., Dean C., Ma H., and Martienssen R. 1995. Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements. Genes Dev. 9: 1797-1810. David Beach Draetta G., Luca F.,Westendorf J., Brizuela L., Ruderman J., and Beach D. 1989. cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. Cell 56: 829-838. DNA Bruce Alberts Introduction: Why the Revolution That Jim Started Continues Joseph F. Sambrook Watson J.D. 1972. Origin of concatemeric T7 DNA. Nat. New Biol. 239: 197-201. Bruce Stillman Prelich G., Kostura M., Marshak D.R., Mathews M.B., and Stillman B. 1987. The cell cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro. Nature 326: 471-475. Bruce Stillman Bell S.P. and Stillman B. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357: 128-134. Richard J. Roberts Klimasauskas S., Kumar S., Roberts R.J., and Cheng X. 1994. HhaI methyltransferase flips its target base out of the DNA helix. Cell 76: 357-369. CELL BIOLOGY David L. Spector Introduction: From Architecture to Functional Analysis Klaus Weber Lazarides E. and Weber K. 1974. Actin antibody: The specific visualization of actin filaments in non-muscle cells. Proc. Natl. Acad. Sci. 71: 2268-2272. Guenter Albrecht-Buehler Albrecht-Buehler G. 1977. Daughter 3T3 cells. Are they mirror images of each other? J. Cell Biol. 72: 595-603. Dafna Bar-Sagi and James R. Feramisco Bar-Sagi D. and Feramisco J.R. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42: 841-848. Carol W. Greider Harley C.B., Futcher A.B., and Greider C.W. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460. David L. Spector Spector D.L. 1990. Higher order nuclear organization: Three-dimensional distribution of small nuclear ribonucleoprotein particles. Proc. Natl. Acad. Sci. 87: 147-151. TUMOR VIRUSES Joseph F. Sambrook Introduction: The Early Days of Tumor Virus Research at Cold Spring Harbor Joseph F. Sambrook Sambrook J., Sharp P.A., and Keller W. 1972. Transcription of simian virus 40. I. Separation of the strands of SV40 DNA and hybridization of the separated strands to RNA extracted from lytically infected and transformed cells. J. Mol. Biol. 70: 57-71. Terri Grodzicker Grodzicker T., Williams J., Sharp P., and Sambrook J. 1974. Physical mapping of temperature-sensitive mutations of adenoviruses. Cold Spring Harbor Symp. Quant. Biol. 39(Pt 1): 439-446. Louise T. Chow Chow L.T., Gelinas R.E., Broker T.R., and Roberts R.J. 1977. An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell 12: 1-8. Michael Botchan Botchan M., Topp W., and Sambrook J. 1976. The arrangement of simian virus 40 sequences in the DNA of transformed cells. Cell 9: 269-287. Robert Tjian Tjian R. 1978. The binding site on SV40 DNA for a T antigen-related protein. Cell 13: 165-179. Joseph F. Sambrook Gluzman Y. 1981. SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23: 175-182. Carl S. Thummel Thummel C., Tjian R., and Grodzicker T. 1981. Expression of SV40 T antigen under control of adenovirus promoters. Cell 23: 825-836. Winship Herr Herr W. and Clarke J. 1986. The SV40 enhancer is composed of multiple functional elements that can compensate for one another. Cell 45: 461-470. NEUROSCIENCE Eric Kandel Introduction: Neuroscience at CSH Laboratory: Meetings, Courses, and Research Ron McKay Introduction: Getting the Point at Cold Spring Harbor Birgit Zipser Zipser B. and McKay R. 1981. Monoclonal antibodies distinguish identifiable neurons in the leech. Nature 289: 549-554. Ron McKay Hockfield S. and McKay R.D.G. 1985. Identification of major cell classes in the developing mammalian nervous system. J. Neurosci. 5: 3310-3328. Tim Tully Yin J.C.P.,Wallach J.S., Del Vecchio M.,Wilder E.L., Zhou H., Quinn W.G., and Tully T. 1994. Induction of a dominant negative CREB transgene specifically blocks longterm memory in Drosophila. Cell 79: 49-58. CANCER Arnold J. Levine Introduction: The Road to Understanding the Origins of Cancer in Humans Mitchell Goldfarb Goldfarb M., Shimizu K., Perucho M., and Wigler M. 1982. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 296: 404-409. Earl Ruley Ruley H.E. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature 304: 602-606. Scott Powers Kataoka T., Powers S., Cameron S., Fasano O., Goldfarb M., Broach J., and Wigler M. 1985. Functional homology of mammalian and yeast RAS genes. Cell 40: 19-26. Douglas Hanahan Hanahan D. 1985. Heritable formation of pancreatic b2;-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115-122. B. Robert Franza, Jr. Franza B.R. Jr., Rauscher F.J. 3rd, Josephs S.F., and Curran T. 1988. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239: 1150-1153. Ed Harlow Whyte P., Buchkovich K.J., Horowitz J.M, Friend S.H., Raybuck M., Weinberg R.A., and Harlow E. 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334: 124-129. TECHNIQUES Angela N.H. Creager Introduction: Early Technological Breakthroughs at Cold Spring Harbor Richard J. Roberts Roberts R.J. 1978. Restriction and modification enzymes and their recognition sequences. Gene 4: 183-194. James I. Garrels Garrels J.I. 1989. The QUEST system for quantitative analysis of two-dimensional gels. J. Biol. Chem 264: 5269-5282. Joseph F. Sambrook Sharp P.A., Sugden B., and Sambrook J. 1973. Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis. Biochemistry 12: 3055-3063. Tom Maniatis Maniatis T., Kee S.G., Efstratiadis A., and Kafatos F.C. 1976. Amplification and characterization of a b2;-globin gene synthesized in vitro. Cell 8: 163-182. Author Index Index

Szczegóły: Life Illuminated - J Witkowski

Tytuł: Life Illuminated
Autor: J Witkowski
Producent: Cold Spring Harbor Laboratory Press
ISBN: 9780879698041
Rok produkcji: 2007
Ilość stron: 242
Oprawa: Twarda
Waga: 0.72 kg

Recenzje: Life Illuminated - J Witkowski