Opis: Neurodegeneration - Salvatore Guccione

Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed "amyloid") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitable pharmacological target. However, drugs aimed at simply removing excess metals or interfering in amyloid deposition were unsuccessful and scientists have been forced to review the classical hypothesis. The latest advances suggest that deficiencies in protein homeostasis may lead to cell dysfunction and disease. Furthermore, small molecules with the potential to control metal homeostasis, or metallostasis, are expected to provide the framework for the design of novel proteostasis regulators. This book provides an up-date on the latest developments in this fast moving field. Traditional views concerning the relationship between the physio-pathological cycles of copper, zinc, iron, aluminium and the evolution of life, are compared with emerging ideas in the neuroscience of metal ions. Topics covered emphasize the importance of metals and oxidation chemistry to neuroscientists as well as providing a wider, multidisciplinary background to chemists who are attracted by these fascinating subjects. The text starts with a chapter on chemical evolution, the brain and metallomics which describes the brain's natural defences to adverse conditions. It then goes on to cover the chemistry and biology of proteostasis, environmental factors, and the role played by membranes in protein misfolding. The remaining chapters cover the role of metals and oxidative stress in Alzheimer's Disease, Parkinsonism, ALS and other neurodegenerative diseases. The book is suitable for academics, those working in industry, and postgraduate students.

The RSC Drug Discovery series presents a good insight into many aspects of drug discovery. In my new role transitioning from a long career in the pharmaceutical industry to academia, the RSC Drug Discovery series will help facilitate my mission of providing students, faculty and future researchers with a good understanding of modern drug discovery.Magid Abou-Gharbia, Professor of Medicinal ChemistryDirector Moulder Center for Drug Discovery and Biomedical Research, Temple University, USAChemical evolution, brain and metallomics; Chemistry and biology of proteostasis; Environmental factors affecting cellular proteostasis; Neurodegeneration and cell membranes; The role of Metals in the intracellular clearance of amyloids; Speciation, coordination sites and metal binding affinities of proteins related to neurodegeneration; Copper, Zinc and trophic factors in neurodegeneration; Metals as catalysts of ROS production in neurodegeneration; Metal hypothesis of Alzheimer disease; Copper supply and metal homeostasis in AD; The role of iron in neurodegeneration; Aluminium in neurodegenerative diseases; Zinc trafficking in the AD brain; The role of metal ions in the pathogenesis of Parkinson's disease; Metals in ALS pathology; Metals and prion diseases

Szczegóły: Neurodegeneration - Salvatore Guccione

Tytuł: Neurodegeneration
Autor: Salvatore Guccione
Producent: Royal Society of Chemistry
ISBN: 9781849730501
Rok produkcji: 2011
Ilość stron: 286
Oprawa: Twarda
Waga: 0.58 kg

Recenzje: Neurodegeneration - Salvatore Guccione