Opis: Synthetic Methods for Biologically Active Molecules

This ready reference focuses on the currently available toolbox of biocatalysed reductions of C=O, C=C and formal C=N double bonds to show which transformations are reliable for use in manufacturing processes and which still require improvements and investigation. Following an introductory chapter, chapters 2-4 present the synthetic strategies which are currently available for the reduction of C=C, C=O and for reductive amination, by means of whole cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the versatility that is currently possible in adapting the enzymes to the requests of organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final two chapters describe the actual practical applications of bioreductions for the synthesis of active pharmaceutical ingredients, and for flavors and fragrances. With its excellent and comprehensive overview, this will be of great interest for those working in academia and industry.INTRODUCTION Development of sustainable biocatalysed reduction processes for organic chemists. Why is this necessary? STATE OF THE ART OF SYNTHETIC STRATEGIES BASED ON BIOCATALYSED REDUCTIONS Synthetic strategies based on C=C bioreductions for the preparation of biologically active molecules Synthetic strategies based on C=O bioreductions for the preparation of biologically active molecules Synthetic applications of biocatalysed reductive aminations for the preparation of biologically active molecules IMPROVEMENTS DUE TO MODIFICATIONS OF THE ENZYMES Strategies for cofactor regeneration in biocatalysed reductions Solvent effects in bioreductions Perspectives in the use of in-situ product removal (ISPR) techniques in bioreductions Multi-enzymatic cascade reactions based on reduction processes Dynamic kinetic resolutions based on reduction processes EXAMPLES OF PRACTICAL APPLICATIONS OF BIOREDUCTIONS Relevant practical applications of bioreduction processes in the synthesis of active pharmaceutical ingredients Relevant practical applications of bioreduction processes in the synthesis of flavours and fragrances

Szczegóły: Synthetic Methods for Biologically Active Molecules

Tytuł: Synthetic Methods for Biologically Active Molecules
Producent: VCH
ISBN: 9783527333875
Rok produkcji: 2013
Ilość stron: 408
Oprawa: Twarda
Waga: 1.02 kg

Recenzje: Synthetic Methods for Biologically Active Molecules