Opis: Carotenoids and Retinal Disease - John T. Landrum

The macular carotenoids play key roles in eye health and retinal disease. Age-related macular degeneration (AMD), the most common cause of acquired blindness in much of the world, is associated with low levels of macular pigment. Macular pigment is also essential for enhancing visual performance by reducing glare disability and improving photostress recovery. Carotenoids and Retinal Disease presents an up-to-date, thorough volume devoted to the chemistry, pathobiology, visual science, and medical and public health significance of the macular carotenoids. With contributions from an international group of leading experts, this book covers a range of topics, from macular anatomy to clinical trials. It begins with a chapter tracing the discovery of macular pigment through the more recent functional recognition of carotenoids. The text covers AMD risk factors, epidemiology, pathogenesis, and classifications. It reviews evidence from epidemiological studies of relationships between AMD and the carotenoids lutein, zeaxanthin, and meso-zeaxanthin, as well as evidence from clinical trials on the effects of macular carotenoid supplementation in subjects with AMD and normal subjects. The book explores the use of molecular genetics in studying macular pigment and AMD pathogenesis; bioavailability of macular pigment; functions of lutein, zeaxanthin, and meso-zeaxanthin; and the identification of macular carotenoid binding proteins involved in pigment uptake and transport. It also covers xanthophyll-membrane interactions, and the macular carotenoids in human serum and their capacity to protect against AMD. Further, the implications of light distribution on the retina for AMD are discussed. Advancing our understanding of how the macular carotenoids enhance vision and prevent vision loss, this book provides a valuable reference for researchers and clinicians involved in the treatment and prevention of retinal disease.Macular Pigment: From Discovery to Function John T. Landrum, Richard Bone, Martha Neuringer, and Yisi Cao Risk Factors for Age-Related Macular Degeneration and Their Relationship with the Macular Carotenoids Tos T.J.M. Berendschot Epidemiology and Aetiopathogenesis of Age-Related Macular Degeneration Sobha Sivaprasad and Phil Hykin Relationships of Lutein and Zeaxanthin to Age-Related Macular Degeneration: Epidemiological Evidence Julie A. Mares Clinical Trials Investigating the Macular Carotenoids Sarah Sabour-Pickett, John M. Nolan, and Stephen Beatty The Promise of Molecular Genetics for Investigating the Influence of Macular Xanthophylls on Advanced Age-Related Macular Degeneration John Paul SanGiovanni and Martha Neuringer A Review of Recent Data on the Bioavailability of Lutein and Zeaxanthin Mareike Beck and Wolfgang Schalch Multiple Influences of Xanthophylls Within the Visual System Billy R. Hammond and James G. Elliott Transport and Retinal Capture of the Macular Carotenoids Binxing Li and Paul S. Bernstein Measurement and Interpretation of Macular Carotenoids in Human Serum David I. Thurnham, Katherine A. Meagher, Eithne Connolly, and John M. Nolan Xanthophyll-Membrane Interactions: Implications for Age-Related Macular Degeneration Witold k. Subczynski, Anna Wisniewska-Becker, and Justyna Widomska Light Distribution on the Retina: Implications for Age-Related Macular Degeneration Richard A. Bone, Jorge C. Gibert, and Anirbaan Mukherjee Index

Szczegóły: Carotenoids and Retinal Disease - John T. Landrum

Tytuł: Carotenoids and Retinal Disease
Autor: John T. Landrum
Producent: CRC Press Inc.
ISBN: 9781466502048
Rok produkcji: 2013
Ilość stron: 272
Oprawa: Twarda

Recenzje: Carotenoids and Retinal Disease - John T. Landrum