Opis: Chemistry of Metalloproteins - Anthony Addison, Joseph Stephanos

This book addresses the full gamut of questions in metalloprotein science. Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations; Metalloenzymes; Copper proteins; Iron proteins; Vitamin B 12; and Chlorophyll. Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.Preface ix 1 Introduction 1 Proteins: Formation, Structures, and Metalloproteins, 4 References, 28 2 Alkali and Alkaline Earth Cations 31 References, 67 3 Nonredox Metalloenzymes 71 Carboxypeptidases, 75 Carbonic Anhydrase, 84 Alcohol Dehydrogenase, 88 References, 91 4 Copper Proteins 95 Introduction, 95 Electronic Spectra of Copper Ions, 96 ESR Spectra of Copper Ions, 105 Copper Proteins, 117 Plastocyanin, 119 Azurin and Stellacyanin, 127 Superoxide Dismutase, 131 Hemocyanin, 135 Ascorbic Oxidase, 139 References, 142 5 Iron Proteins 147 Introduction, 147 Electronic Spectra of Iron Ions, 148 Mossbauer Spectroscopy of Iron Ions, 155 ESR Spectra of Iron (III), 161 Iron Bioavailability, 166 Siderophores, 171 Iron Storage and Transfer Proteins, 184 Ferritin, 184 Transferrin, 187 Dioxygenase Iron Proteins, 195 Iron--Sulfur Proteins, 207 Rubredoxin, 207 Ferredoxins, 212 2Fe--2S Ferredoxins, 212 4Fe--4S Ferredoxins, 221 Aconitase, 226 Hydroxylases, 229 Hydrogenases, 232 Nitrogenases, 240 Binuclear Iron Proteins, 251 Hemerythrin, 253 Ribotide Reductase, Purple Acid Phosphate, and Methane Monooxygenase, 260 Hemoproteins: Classification and Behavior of Heme in Absence of Globins, 267 Myoglobin and Hemoglobin, 275 Myoglobin, 275 Hemoglobin, 280 Cytochrome C, 298 Electron Transfer in Porphyrins and Metalloporphyrins, 301 Catalases, 311 Peroxidases, 315 Cytochrome P-450, 322 Electronic Spectra of Hemoproteins, 327 ESR Spectra of Hemoproteins, 362 References, 378 6 Vitamin B12 393 References, 405 7 Chlorophyll 407 References, 421 Index 423

Szczegóły: Chemistry of Metalloproteins - Anthony Addison, Joseph Stephanos

Tytuł: Chemistry of Metalloproteins
Autor: Anthony Addison, Joseph Stephanos
Producent: John Wiley
ISBN: 9781118470442
Rok produkcji: 2014
Ilość stron: 448
Oprawa: Miękka
Waga: 0.65 kg

Recenzje: Chemistry of Metalloproteins - Anthony Addison, Joseph Stephanos