Opis: Radiosensitizers and Radiochemotherapy in the Treatment of Cancer - Shirley Lehnert

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must now address a huge range of topics, covering everything from molecular oxygen and high Z elements to monoclonal antibodies and complex phytochemicals. At the molecular level, the understanding of the molecular consequences of DNA damage and the DNA damage response have informed the development of targeted radiosensitizers and shed light on the mode of action of radiochemotherapy protocols of known clinical efficacy. In this book the mechanisms of action at the molecular and cellular level are described for documented radiosensitizers including, where applicable, a brief history of their clinical use and most recent clinical results. In addition, the clinical context is addressed including the importance of factors such as dose and dose rate, normal tissue toxicity, and drug delivery. Intuitively organized by topic and application, the book includes extensive illustrations, end-of-chapter summaries, and a wealth of references.Radiosensitization and Chemoradiation A Brief History of Chemoradiation Definitions of Radiosensitization What This Book Is About Summary References Radiosensitization by Oxygen and Nitric Oxide Radiosensitization by Oxygen: The Oxygen Fixation Hypothesis Nitric Oxide: A Versatile Small Molecule Summary References Radioenhancement by Targeting Cellular Redox Pathways and/or by Incorporation of High-Z Materials into the Target Introduction Dose Enhancement by Compounds with High Atomic Number Targeting Cellular Redox Pathways Radiosensitization by Targeting the GSH/GSSG System Summary References Radiosensitization by Halogenated Pyrimidines Halogenated Pyrimidines Mechanisms of Radiosensitization Clinical Results Summary References Radiosensitization by Antimetabolites Antimetabolites Antimetabolites: Mode of Action Inhibitors of Thymidy late Synthase: 5-FU and FDURD Inhibitors of Ribonucleotide Reductase DNA Polymerase Inhibitors/Substrates New Generation Antimetabolites Summary References Radiosensitization by Platinum Drugs and Alkylating Agents The Platinum Drugs Alkylating Agents Summary References Topoisomerase Inhibitors and Microtubule-Targeting Agents Radiosensitization by Drugs Targeting DNA Topology and the Mitotic Spindle Topoisomerases Radiosensitization by Targeting Microtubules Summary References Targeting the DNA Damage Response: ATM, p53, Checkpoints, and the Proteasome The DNA Damage Response ATM Kinase p53 in the DNA Damage Response Targeting Cell Cycle Checkpoint Proteins: CHK1 and CHK2 Protein Degradation by the Ubiquitin-Proteasome System Summary References Radiosensitization by Inhibition of DNA Repair Overview of DNA Repair in Mammalian Cells DNA Double-Strand Break Repair: Nonhomologous End-Joining DNA Double-Strand Break Repair by Homologous Recombination Radiosensitization by Inhibitors of Poly(ADP-Ribose) Polymerase Inhibitors of Histone Deacetylase: Targeting Chromatin Modification by Epigenetic Regulation of Gene Expression Summary References Targeting Growth Factor Receptors for Radiosensitization Epidermal Growth Factor Family Receptors ErbB2 (HER2) Insulin-Like Growth Factor 1 Receptor Summary References Targeting Signaling Molecules for Radiosensitization Ras Cytoplasmic Signaling Downstream from Ras Targeting Hsp90 Summary References Radiosensitization by Targeting the Tumor Microenvironment The Tumor Microenvironment Tumor Vasculature and Angiogenesis Tumor Characteristics Exploitable for Radiosensitization: Hypoxia Vascular Targeted Therapies Antivascular Therapy Targeting HIF-1 Summary References Phytochemicals: Chemopreventive, Radiosensitizing, Radioprotective Mechanism of Interaction Between Phytochemicals and Proteins Intracellular Systems and Constituent Proteins Directly Targeted by Curcumin and Other Radiosnsitizing Phytochemicals Targeting Proinflammatory Signaling Pathways for Tumor Radiosensitization Phytochemicals that Have Been Shown to Act as Radiosensitizers Radioprotection by Phytochemicals: Targeting the Proinflammatory Response to Reduce the Side Effects of Radiation Clinical Applications of Phytochemicals Summary References Delivery Methods for Radioenhancing Drugs Delivery of Radiosensitizing Drugs Intratumoral Sustained Drug Release Devices Summary References

Szczegóły: Radiosensitizers and Radiochemotherapy in the Treatment of Cancer - Shirley Lehnert

Tytuł: Radiosensitizers and Radiochemotherapy in the Treatment of Cancer
Autor: Shirley Lehnert
Producent: CRC Press Inc.
ISBN: 9781439829028
Rok produkcji: 2014
Ilość stron: 548
Oprawa: Twarda

Recenzje: Radiosensitizers and Radiochemotherapy in the Treatment of Cancer - Shirley Lehnert