Opis: Genetic Analysis: An Integrated Approach - John Bowman, Mark Frederick Sanders

For all introductory genetics courses Informed by many years of genetics teaching and research expertise, authors Mark Sanders and John Bowman use an integrated approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding the connection between traditional genetics models and more modern approaches. Genetic Analysis: An Integrated Approach, 2/e is extensively updated with relevant, cutting-edge coverage of modern genetics and is supported by MasteringGenetics, the most widely-used homework and assessment program in genetics. Featuring expanded assignment options, MasteringGenetics complements the book's problem-solving approach, engages students, and improves results by helping them master concepts and problem-solving skills. MasteringGenetics is not included. Students, if MasteringGenetics is a recommended/mandatory component of the course, please ask your instructor for the correct ISBN and course ID. MasteringGenetics should only be purchased when required by an instructor. Instructors, contact your Pearson representative for more information. MasteringGenetics is an online homework, tutorial, and assessment program designed to work with this text to engage students and improve results. Interactive, self-paced tutorials provide individualized coaching to help students stay on track. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts.BRIEF CONTENTS 1 The Molecular Basis of Heredity, Variation, and Evolution 1.1 Modern Genetics Is in Its Second Century 1.2 The Structure of DNA Suggests a Mechanism for Replication 1.3 DNA Transcription and Messenger RNA Translation Express Genes 1.4 Evolution Has a Molecular Basis Case Study The Modern Human Family Mystery Summary * Keywords * Problems 2 Transmission Genetics 2.1 Gregor Mendel Discovered the Basic Principles of Genetic Transmission 2.2 Monohybrid Crosses Reveal the Segregation of Alleles 2.3 Dihybrid and Trihybrid Crosses Reveal the Independent Assortment of Alleles 2.4 Probability Theory Predicts Mendelian Ratios 2.5 Chi-Square Analysis Tests the Fit between Observed Values and Expected Outcomes 2.6 Autosomal Inheritance and Molecular Genetics Parallel the Predictions of Mendel's Hereditary Principles Case Study Inheritance of Sickle Cell Disease in Humans Summary * Keywords * Problems 3 Cell Division and Chromosome Heredity 3.1 Mitosis Divides Somatic Cells 3.2 Meiosis Produces Gametes for Sexual Reproduction 3.3 The Chromosome Theory of Heredity Proposes That Genes Are Carried on Chromosomes 3.4 Sex Determination Is Chromosomal and Genetic 3.5 Human Sex-Linked Transmission Follows Distinct Patterns 3.6 Dosage Compensation Equalizes the Expression of Sex-Linked Genes Case Study The (Degenerative) Evolution of the Mammalian Y Chromosome Summary * Keywords * Problems 4 Inheritance Patterns of Single Genes and Gene Interaction 4.1 Interactions between Alleles Produce Dominance Relationships 4.2 Some Genes Produce Variable Phenotypes 4.3 Gene Interaction Modifies Mendelian Ratios 4.4 Complementation Analysis Distinguishes Mutations in the Same Gene from Mutations in Different Genes Case Study Complementation Groups in a Human Cancer-Prone Disorder Summary * Keywords * Problems 5 Genetic Linkage and Mapping in Eukaryotes 5.1 Linked Genes Do Not Assort Independently 5.2 Genetic Linkage Mapping Is Based on Recombination Frequency between Genes 5.3 Three-Point Test-Cross Analysis Maps Genes 5.4 Recombination Results from Crossing Over 5.5 Linked Human Genes Are Mapped Using Lod Score Analysis 5.6 Recombination Affects Evolution and Genetic Diversity 5.7 Genetic Linkage in Haploid Eukaryotes Is Identified by Tetrad Analysis 5.8 Mitotic Crossover Produces Distinctive Phenotypes Case Study Mapping the Gene for Cystic Fibrosis Summary * Keywords * Problems 6 Genetic Analysis and Mapping in Bacteria and Bacteriophages 6.1 Bacteria Transfer Genes by Conjugation 6.2 Interrupted Mating Analysis Produces Time-of-Entry Maps 6.3 Conjugation with F Strains Produces Partial Diploids 6.4 Bacterial Transformation Produces Genetic Recombination 6.5 Bacterial Transduction Is Mediated by Bacteriophages 6.6 Bacteriophage Chromosomes Are Mapped by Fine-Structure Analysis 6.7 Lateral Gene Transfer Alters Genomes Case Study The Evolution of Antibiotic Resistance and Change in Medical Practice Summary * Keywords * Problems 7 DNA Structure and Replication 7.1 DNA Is the Hereditary Molecule of Life 7.2 The DNA Double Helix Consists of Two Complementary and Antiparallel Strands 7.3 DNA Replication Is Semiconservative and Bidirectional 7.4 DNA Replication Precisely Duplicates the Genetic Material 7.5 Molecular Genetic Analytical Methods Make Use of DNA Replication Processes Case Study Use of PCR and DNA Sequencing to Analyze Huntington Disease Mutations Summary * Keywords * Problems 8 Molecular Biology of Transcription and RNA Processing 8.1 RNA Transcripts Carry the Messages of Genes 8.2 Bacterial Transcription Is a Four-Stage Process 8.3 Archaeal and Eukaryotic Transcription Displays Structural Homology and Common Ancestry 8.4 Post-Transcriptional Processing Modifies RNA Molecules Case Study Sexy Splicing: Alternative mRNA Splicing and Sex Determination in Drosophila Summary * Keywords * Problems 9 The Molecular Biology of Translation 9.1 Polypeptides Are Composed of Amino Acid Chains That Are Assembled at Ribosomes 9.2 Translation Occurs in Three Phases 9.3 Translation Is Fast and Efficient 9.4 The Genetic Code Translates Messenger RNA into Polypeptide 9.5 Experiments Deciphered the Genetic Code 9.6 Translation Is Followed by Polypeptide Folding, Processing, and Protein Sorting Case Study Antibiotics and Translation Interference Summary * Keywords * Problems 10 The Integration of Genetic Approaches: Understanding Sickle Cell Disease 10.1 An Inherited Hemoglobin Variant Causes Sickle Cell Disease 10.2 Genetic Variation Can Be Detected by Examining DNA, RNA, and Proteins 10.3 Sickle Cell Disease Evolved by Natural Selection in Human Populations Case Study Transmission and Molecular Genetic Analysis of Thalassemia Summary * Keywords * Problems 11 Chromosome Structure 11.1 Viruses Are Infectious Particles Containing Nucleic Acid Genomes 11.2 Bacterial Chromosomes Are Organized by Proteins 11.3 Eukaryotic Chromosomes Are Organized into Chromatin 11.4 Chromatin Compaction Varies along the Chromosome 11.5 Chromatin Organizes Archaeal Chromosomes Case Study Fishing for Chromosome Abnormalities in Cancer Cells Summary * Keywords * Problems 12 Gene Mutation, DNA Repair, and Homologous Recombination 12.1 Mutations Are Rare and Occur at Random 12.2 Gene Mutations Modify DNA Sequence 12.3 Gene Mutations May Arise from Spontaneous Events 12.4 Mutations May Be Induced by Chemicals or Ionizing Radiation 12.5 Repair Systems Correct Some DNA Damage 12.6 Proteins Control Translesion DNA Synthesis and the Repair of Double-Strand Breaks 12.7 DNA Double-Strand Breaks Initiate Homologous Recombination 12.8 Gene Conversion Is Directed Mismatch Repair in Heteroduplex DNA Case Study Li-Fraumeni Syndrome Is Caused by Inheritance of Mutations of p53 Summary * Keywords * Problems 13 Chromosome Aberrations and Transposition 13.1 Nondisjunction Leads to Changes in Chromosome Number 13.2 Changes in Euploidy Result in Various Kinds of Polyploidy 13.3 Chromosome Breakage Causes Mutation by Loss, Gain, and Rearrangement of Chromosomes 13.4 Chromosome Breakage Leads to Inversion and Translocation of Chromosomes 13.5 Transposable Genetic Elements Move throughout the Genome 13.6 Transposition Modifies Bacterial Genomes 13.7 Transposition Modifies Eukaryotic Genomes Case Study Human Chromosome Evolution Summary * Keywords * Problems 14 Regulation of Gene Expression in Bacteria and Bacteriophage 14.1 Transcriptional Control of Gene Expression Requires DNA-Protein Interaction 14.2 The lac Operon Is an Inducible Operon System under Negative and Positive Control 14.3 Mutational Analysis Deciphers Genetic Regulation of the lac Operon 14.4 Transcription from the Tryptophan Operon Is Repressible and Attenuated 14.5 Bacteria Regulate the Transcription of Stress Response Genes and Translation and Archaea Regulate Transcription in a Bacteria-like Manner 14.6 Antiterminators and Repressors Control Lambda Phage Infection of E. coli Case Study Vibrio cholerae-Stress Response Leads to Serious Infection Summary * Keywords * Problems 15 Regulation of Gene Expression in Eukaryotes 15.1 Cis-Acting Regulatory Sequences Bind Trans-Acting Regulatory Proteins to Control Eukaryotic Transcription Transcriptional Regulatory Interactions 15.2 Chromatin Remodeling and Modification Regulates Eukaryotic Transcription 15.3 RNA-Mediated Mechanisms Control Gene Expression Case Study Environmental Epigenetics Summary * Keywords * Problems 16 Analysis of Gene Function via Forward Genetics and Reverse Genetics 16.1 Forward Genetic Screens Identify Genes by Their Mutant Phenotypes 16.2 Genes Identified by Mutant Phenotype Are Cloned Using Recombinant DNA Technology 16.3 Reverse Genetics Investigates Gene Action by Progressing from Gene Identification to Phenotype 16.4 Transgenes Provide a Means of Dissecting Gene Function Case Study Reverse Genetics and Genetic Redundancy in Flower Development Summary * Keywords * Problems 17 Recombinant DNA Technology and Its Applications 17.1 Specific DNA Sequences Are Identified and Manipulated Using Recombinant DNA Technology 17.2 Introducing Foreign Genes into Genomes Creates Transgenic Organisms 17.3 Gene Therapy Uses Recombinant DNA Technology 17.4 Cloning of Plants and Animals Produces Genetically Identical Individuals Case Study Curing Sickle Cell Disease in Mice Summary * Keywords * Problems 18 Genomics: Genetics from a Whole-Genome Perspective 18.1 Structural Genomics Provides a Catalog of Genes in a Genome 18.2 Annotation Ascribes Biological Function to DNA Sequences 18.3 Evolutionary Genomics Traces the History of Genomes 18.4 Functional Genomics Aids in Elucidating Gene Function Case Study Genomic Analysis of Insect Guts May Fuel the World Summary * Keywords * Problems 19 Organelle Inheritance and the Evolution of Organelle Genomes 19.1 Organelle Inheritance Transmits Genes Carried on Organelle Chromosomes 19.2 Modes of Organelle Inheritance Depend on the Organism 19.3 Mitochondria Are the Energy Factories of Eukaryotic Cells 19.4 Chloroplasts Are the Sites of Photosynthesis 19.5 The Endosymbiosis Theory Explains Mitochondrial and Chloroplast Evolution Case Study Ototoxic Deafness: A Mitochondrial Gene-Environment Interaction Summary * Keywords * Problems 20 Developmental Genetics 20.1 Development Is the Building of a Multicellular Organism 20.2 Drosophila Development Is a Paradigm for Animal Development 20.3 Cellular Interactions Specify Cell Fate 20.4 "Evolution Behaves Like a Tinkerer" 20.5 Plants Represent an Independent Experiment in Multicellular Evolution Case Study Cyclopia and Polydactyly-Different Shh Mutations with Distinctive Phenotypes Summary * Keywords * Problems 21 Genetic Analysis of Quantitative Traits 21.1 Quantitative Traits Display Continuous Phenotype Variation 21.2 Quantitative Trait Analysis Is Statistical 21.3 Heritability Measures the Genetic Component of Phenotypic Variation 21.4 Quantitative Trait Loci Are the Genes That Contribute to Quantitative Traits Case Study GWAS and Crohn's Disease Summary * Keywords * Problems 22 Population Genetics and Evolution at the Population, Species, and Molecular Levels 22.1 The Hardy-Weinberg Equilibrium Describes the Relationship of Allele and Genotype Frequencies in Populations 22.2 Natural Selection Operates through Differential Reproductive Fitness within a Population 22.3 Mutation Diversifies Gene Pools 22.4 Migration Is Movement of Organisms and Genes between Populations 22.5 Genetic Drift Causes Allele Frequency Change by Sampling Error 22.6 Inbreeding Alters Genotype Frequencies 22.7 Species and Higher Taxonomic Groups Evolve by the Interplay of Four Evolutionary Processes 22.8 Molecular Evolution Changes Genes and Genomes through Time Case Study CODIS-Using Population Genetics to Solve Crime and Identify Paternity Summary * Keywords * Problems Selected References and Readings Answers to Selected Problems Glossary Credits Index

Szczegóły: Genetic Analysis: An Integrated Approach - John Bowman, Mark Frederick Sanders

Tytuł: Genetic Analysis: An Integrated Approach
Autor: John Bowman, Mark Frederick Sanders
Producent: Pearson
ISBN: 9781292092362
Rok produkcji: 2015
Ilość stron: 888
Oprawa: Miękka
Waga: 1.73 kg

Recenzje: Genetic Analysis: An Integrated Approach - John Bowman, Mark Frederick Sanders