Opis: Immunological Mechanism in Asthma - Robinson

This book explores the cellular and molecular mechanisms involved in asthma and allergic diseases, from basic immunology to the treatment of patients. Arising from a special symposium held to celebrate Professor A. Barry Kay's 20th anniversary as Head of the Department of Allergy and Clinical Immunology at the National Heart and Lung Institute, London, the publication presents 18 review articles by an impressive cross section of experts in the field. The topics considered include Th1 and Th2 cells, the regulation of Th2 cytokine transcription, the role of T cells in the immunopathogenesis of asthma, and MHC-restricted IgE-independent T-cell-induced late-phase responses in human subjects. Further chapters focus on eosinophil adhesion and activation, the role of C-C chemokines in the recruitment of eosinophils, and the interactions between eosinophils and fibroblasts. T-cell recruitment and T-cell interactions in cutaneous basophil hypersensitivity and fibrotic lung disease are discussed.Scientific overview of 20 years' work in the Department of Allergy and Clinical Immunology under the guidance of professor A.B. Kay - D.S. Robinson; regulation of Th2 cytokine gene transcription - P.Lavender, D. Cousins, T. Lee; MHC-restricted, IgE-independent, allergen peptide-induced late asthmatic reactions - M. Larche; the role of the T cell in the immunopathogenesis of asthma - C.J. Corrigan; the Th1 and Th2 concept in atopic allergic disease - D.S. Robinson; the bronchial epithelial origins of asthma, S.T. Holgate; molecular basis for corticosteroid action in asthma - P.J. Barnes; mast cell-eosinophil-fibroblast crosstalk in allergic inflammation - S.J. Smith, F. Levi-Schaffer; the role of adhesion in eosinophil function - A.J. Wardlaw; proposing Th2 DTH relevant to asthma - cutaneous basophil hypersensitivity then and now - P.W. Askenase; novel immunosuppressants in asthma - O.M. Kon; T-cell recruitment and specificity in allergic inflammation - A.J. Frew; T cells and fibrosis - B.G. Marshall, R.J. Shaw; molecular pathology of allergic diseases - P. Christodoulopoulos, S. Muro, Q. Hamid; role of eotaxin and related C-C chemokines in allergy and asthma - T.J. Williams, P.J. Jose; C-C chemokine expression in atopic and nonatopic asthma - S. Ying; molecular mechanisms in eosinophil activation - R. Moqbel, P. Lacy; immunotherapy for hayfever - S.R. Durham, S. Walker.

Szczegóły: Immunological Mechanism in Asthma - Robinson

Tytuł: Immunological Mechanism in Asthma
Autor: Robinson
Producent: Karger
ISBN: 9783805571128
Rok produkcji: 2000
Ilość stron: 214
Oprawa: Twarda
Waga: 0.62 kg

Recenzje: Immunological Mechanism in Asthma - Robinson